Depression, classified under mood disorders, remains a well-known mental health concern with accessible treatments.
The prevalence of mood and anxiety disorders in Canada showed an upward trajectory from 2012 to 2022. Some individuals still face challenges in accessing the necessary care.
The reality of treatment-resistant depression has led certain individuals to buy psychedelics online Canada from https://www.zoomiescanada.ca/. Surprisingly, some have found this alternative approach to be effective in addressing their mental health struggles.
Key Takeaways:
- Depression is a prevalent mental health challenge, and its varied treatment approaches don’t always yield positive outcomes for everyone.
- Psychedelics influence the brain in various ways, offering a lasting reduction in symptoms associated with depression.
- Researchers explored LSD and Psilocybin extensively, making them among the most researched psychedelics.
Depression in Adults and Symptoms
Depression is a mood illness with a persistent sense of sadness and a loss of interest in things and activities that you formerly enjoyed. It can also impair thinking, memory, eating, and sleeping.
It’s natural to be sad or cry about terrible life events like losing a job or divorce. However, depression is distinct in that it lasts for at least two weeks.
Depression symptoms vary slightly on the type and can range from minor to severe.
Symptoms in general include:
- Feeling depressed, despondent, or concerned.
- Things that used to offer you delight are no longer bringing you joy.
- The ability to become easily angry or frustrated.
- Eating too much or too little can lead to weight gain or reduction.
- Insomnia (difficulty sleeping) or excessive sleeping (hypersomnia).
- Lack of energy or tiredness.
- You’re having trouble concentrating, making judgments, or remembering things.
- Having physical problems such as a headache, stomachache, or sexual dysfunction.
- Considering self-harm or suicide.
How to Treat Adult Depression
Most patients with depression benefit from antidepressants and psychotherapy. A psychiatrist may recommend medication to help with your symptoms. But for many people, connecting with a mental health professional works.
| MEDICATIONS | PSYCHOTHERAPY |
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You can benefit from psychotherapy in the following ways:
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Why Some People Don’t Respond to Treatment
Many folks don’t seem to find relief with antidepressants, and there’s a prevailing thought that it boils down to a basic misinterpretation of how depression’s biochemistry works.
Many experts in the field believe that depression may stem from insufficient levels of neurotransmitters associated with happiness, while an alternate perspective suggests inflammation as a contributing factor.
A school of thought proposes that Treatment-Resistant Depression could be due to the scarcity of two specific genes for constructing essential brain circuits. Should this theory hold true, it sheds light on why antidepressants geared towards enhancing serotonin or norepinephrine might not be the universal remedy for everyone experiencing depression.
Psychedelics as An Alternative Treatment
Psilocybin
| STUDY | RESULT |
| Johns Hopkins Medicine | Psilocybin proved to be a promising relief for adults grappling with major depressive disorder, significantly easing symptoms for a duration extending up to a month.
In a subsequent analysis of those participants, the antidepressant effects of psilocybin + supportive psychotherapy may continue for at least a year for certain patients. |
| Goodwin et al. | Over three weeks, a single dose of 25 mg of psilocybin lowered depression ratings much more than a 1-mg dose. |
| Carhart-Harris et al | At one week after treatment, all 19 patients had reduced depression symptoms, and 47% satisfied response criteria at five weeks.
CBF decreased throughout the temporal cortex, including the amygdala, after treatment, according to whole-brain studies. Reduced amygdala CBF was associated with fewer depression symptoms. |
LSD
| STUDY | RESULT |
| Denson et al. | There were significant differences in Questionnaire data (BFQNSP), with the LSD treatment group outperforming the control group in terms of overall health at 6 and 12 months. |
| Savage et al. | At 6-8 weeks, most metrics for all three groups showed a substantial improvement. This improvement (primarily in symptomatology and self-actualization) was significantly greater on average for the LSD treatment group versus the “usual treatment” control group. |
| Liechti et al. | 12 months after the trial, 71% of participants rated their LSD experience as “among the ten most meaningful experiences of their lives.” |
DMT
| STUDY | RESULT |
| Routledge et al. | According to data from Small Pharma, 14 of the 25 patients who finished the 6 months of extra follow-up achieved remission during the original 3-month study period.
At 6 months, 9 of the 14 “prior remitters” (64%) remained in remission. Ten (40%) of the 25 patients who completed the 6-month follow-up met the criteria for remission. |
| D’Souza et al. | Intravenous DMT at 0.1 and 0.3 mg/kg doses was mainly safe and tolerated in this short exploratory pilot research.
It may provide next-day (rapid) antidepressant benefits in individuals with treatment-resistant MDD. |
How Psychedelics Work in General
- Psychedelics work their magic on the brain by engaging with a special cellular buddy called the 5-HT2AR. They foster the flexibility of neurons.
- Functional MRI brain scans have unveiled the intriguing impact of psilocybin. It seems to dial down the hustle in the medial prefrontal cortex, a brain zone for juggling various cognitive tasks. This mystical compound also throws a twist into the mix by loosening the ties between this region and the posterior cingulate cortex.
- Psychedelics alleviate depressed symptoms by focusing on presumed underlying pathophysiology or biological imbalance.
Psychedelic Products for Depression
| PRODUCT | PSYCHEDELIC TYPE | DOSAGE/ POTENCY |
| Golden Teacher (dried shrooms) | Psilocybin | Average |
| Evoke – Medicinal Mushrooms – Microdose Capsules | Psilocybin | 100/200mg x 20 capsules |
| PRISM – Tabs | LSD | 100μg |
| Lucid Supply Co. – Liquid Solution | LSD | 930μg – (31μg/ml) |
| Integral Alchemist – Acacia Vape Cart | DMT | 1 mL |
| Lucid Supply Co. – Pure Crystal (Freebase) | 5-MeO DMT | 500mg |
Conclusion
As researchers delve deeper into exploring alternative treatments for depression and other mental illnesses, the potential to assist patients continues to grow. Even though psychedelics are still in the early phases of development, they are already instilling hope in patients seeking innovative therapeutic options. Because of the encouraging results, patients are seeking psychedelic products from trusted online sellers.
Frequently Asked Questions
What are the different psychedelics available online in Canada?
| LSD | Lysergic acid diethylamide can profoundly alter individuals’ perceptions and emotions, creating a unique and transformative experience.
Its roots trace back to “ergot,” a fungus that makes itself home on rye and various grains. |
| Magic mushroom | Shrooms are something people might take to experience a shift in their thoughts and feelings. |
| DMT | N, N-dimethyltryptamine, found in various plants, can also be synthesized in a laboratory setting.
Colloquial names: Dimitri or Fantasia |
Are psychedelics affordable?
With a diverse selection of products, even those crafted with premium ingredients won’t break the bank, typically capping at $150. Online dispensaries pass on the savings to you, thanks to their lower overhead costs and expansive market reach. While tempting bargains may catch your eye, take a moment to compare prices and ensure you’re getting the best value for your experience.
How to make sure the psychedelic product is real?
- Look for reviews, testimonials, and ratings from other buyers. A reputable and trustworthy seller is more likely to provide genuine products.
- Know its characteristics, appearance, and common variations. This knowledge can help you identify red flags if the product you receive deviates significantly from the expected norms.
- A reliable seller will be transparent about their products, sourcing, and testing procedures. Ask about the product’s origin, manufacturing process, and any third-party testing conducted.
- Legitimate sellers focus on providing accurate information about the product rather than making exaggerated promises.
- If a bargain appears to be too good to be true, it could be an indication of fraud.
What is the best psychedelic product?
It all comes down to your particular preferences when it comes to getting the perfect psychedelic experience for you.
- Select between LSD, magic mushrooms, or DMT.
- Make a choice between edibles, dried mushrooms, tinctures, vapes, drinks, etc.
- Consider if you are going to microdose or macrodose.
- Check the price.
Where to buy psychedelics?
Purchasing psychedelics online offers a secure and hassle-free way to access these substances.
- Online dispensaries have a broader range of psychedelic products compared to local sources. This allows consumers to explore options and find products that suit their preferences or meet specific needs.
- Many online platforms feature customer reviews and ratings. These can be valuable resources for potential buyers.
- Purchasing psychedelics online eliminates the need for physical travel and potentially uncomfortable face-to-face interactions.
- Numerous opportunities exist to trim down the overall cost of the product through sales, promotions, and discounts.
